N,N-Dimethyltryptamine (also known as DMT, N,N-DMT, Dimethyltryptamine, Dmitri, and “The Spirit Molecule”) is an infamous naturally-occurring psychedelic substance of the tryptamine chemical class that produces an unusually intense, short-lived version of what has come to be considered the “classical psychedelic”experience (i.e. those traditionally associated with Mescaline, Psilocybin Mushrooms, DMT, and LSD) when administered.
Depending on the dosage and method of administration, the effects of DMT can range from mild psychedelic states to powerfully immersive life-altering experiences which are often described as the ultimate displacement from ordinary consciousness, in which users are placed in a subjective state where they can experience exploring ineffable spiritual realms or alternate dimensions.
DMT is present in over 65 species of plants and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout the plant kingdom. Although various theories have been postulated, the substance’s neurobiological function has yet to be determined.
In modern times, DMT is viewed as an extremely powerful visionary psychedelic entheogen that, when vaporized or smoked, produces short-lived effects with a very rapid onset that are sometimes compared to an “unimaginably high-speed roller-coaster ride.” When ingested in combination with a MAOI or RIMA agent, it becomes active orally and thus significantly longer lasting, immersive, and interactive in nature; this combination is known as ayahuasca. Ayahuasca brews have been used traditionally in South America since at least around the year 1500.
Unlike most highly prohibited substances, DMT is not considered to be physiologically toxic or addictive by the scientific community. Nevertheless, unpredictable adverse reactions such as anxiety, paranoia, delusions and psychotic breaks can always still occur, particularly among those predisposed to psychiatric disorders.While these negative reactions or “bad trips” can often be attributed to user inexperience or improper preparation of set and setting, they have been known to happen spontaneously among even the most experienced of users as well.
DMT, or N,N-dimethyltryptamine, is a naturally-occurring indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. DMT contains two methyl groups (CH3-) bound to the terminal amine RN at the end of this chain. DMT has many homologs and analogs from base tryptamines like MET and DPT, to four and five position substituted variants such as 4-PO-DMT (Psilocybin), 4-AcO-DMT (Psilacetin), and 5-MeO-DMT.
DMT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
In addition to this, N,N-dimethyltrytamine is believed to be an endogenous ligand for the sigma receptor. However, the significance of the sigma-1 receptor remains the subject of ongoing scientific research.
The compound’s affinities for various receptor sets have been well-studied and are listed in the table below:
|Binding Sites||Binding Affinity Ki (nM)|
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death (via behavorial toxicity).
- Spontaneous physical sensations – The “body high” of DMT can be described as a pleasurable all-encompassing glow. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached. It is capable of becoming very powerful at higher doses and can remain for up to half an hour after the trip itself has ended.
- Changes in felt gravity – At higher breakthrough doses, physical feelings of being launched across vast distances at incredibly high speeds are commonly reported.
- Spatial disorientation
- Changes in felt bodily form
- Physical autonomy
- Nausea – This effect is much less common than it is with 5-MeO-DMT as well as longer-lasting psychedelics like psilocybin mushrooms or mescaline. It can still, however, manifest spontaneously and sometimes lead to sudden bouts of vomiting.
- Pupil dilation
- Increased heart rate
- Temperature regulation suppression
- Seizure – This is a very rare effect but can happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished.
- Drifting (melting, breathing, morphing and flowing) – In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion and static in its appearance.
- Colour replacement
- Colour shifting
- Colour tinting
- After images
- Scenery slicing
- Symmetrical texture repetition
- Environmental geometry
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of psilocin than LSD. It can be comprehensively described through its variations as intricate in complexity, abstract in form, equally organic and digital in feel, structured in organization, brightly lit, multicoloured in scheme, glossy in shading, equal in sharp and soft edges, large in size, fast in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in its intensity. At higher doses, it is significantly more likely to result in states of level 8B visual geometry over level 8A.
The geometry present with smokeable DMT is considered by many to be the most profoundly intricate and complex set of visual geometry found within the entirety of the psychedelic experience. In comparison to orally active DMT (ayahuasca), it is significantly more digital in appearance and contains a colour scheme which is similar to LSD and a structured style that resembles a high dose of psilocin (4-HO-DMT).
DMT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic. These effects include:
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) – DMT produces high level internal hallucinations at appropriate doses more consistently than that of any other psychedelic. They are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- External hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) – These are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- DMT in its smokeable form is perhaps the least psychologically intoxicating psychedelic. It is due to this lack of perceived intoxication that many people describe DMT as a genuine experience that is actually happening to them. It is worth noting that many people report that DMT is extremely clear-headed in its style and contains less personal insight in comparison to orally active psychedelics such as ayahuasca, LSD and psilocybin due to its short-acting nature.
- Analysis enhancement
- Déjà vu
- Ego replacement
- Emotion enhancement
- Cognitive euphoria
- Feelings of impending doom
- Increased music appreciation – This typically occurs only at lower sub-breakthrough doses, and is not as prominent of an effect as it is with longer lasting psychedelics like LSD or psilocybin. Many people prefer to have their DMT experiences in complete silence, other than shutting out perceptual distractions this is often done to prevent a “sensory overload” or an overwhelming experience.
- Memory suppression
- Mindfulness – This effect tends to occur after the trip has ended and the individual has returned to ordinary waking consciousness, to a sense of presence and sensitivity towards one’s inner sensations as well as outer environment.
- Multiple thought streams – This effect tends to manifest in a much more chaotic fashion, in tandem with the sensation of cognitive overload.
- Novelty enhancement
- Personal bias suppression
- Rejuvenation – This effect tends to occur after the trip has ended and the subject has returned to ordinary waking consciousness, often in Near-Death Experience (NDE) variants of a DMT experience.
- Subconscious communication
- Time distortion – This effect is a very prominent aspect of the DMT experience, which only tends to last under 15 minutes but is commonly reported to subjectively feel as if it had lasted much longer, in some cases “many lifetimes” or even an “eternity”. This particular effect is most prevalent and notable with “breakthrough” experiences. 
- Synaesthesia – In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
- Note: For a number of individuals these effects are consistently more reproducible and powerful with smoked or vaporized DMT than they are with other “classical psychedelics” such as LSD or mescaline, this is most likely due to its very intense but relatively short-lived effects. These components are unique to DMT in that for a majority of its users they are significantly more likely to manifest during “breakthrough” experiences as opposed to sub-breakthrough level trips.
Anecdotal reports which describe the effects of this compound within our experience index include:
- Dmt brazil/Vinegar/Lime ab Extraction Tek
- Experience:2.5g Mushrooms + 500mg DMT
- Experience:25mg DMT – Your wall can’t save you
- Experience:30mg (smoked) DMT – The Monolith
- Experience:337mg DMT fumurate – A Day With DMT
- Experience:40mg (smoked) – The planet became a watermelon
- Experience:40mg – Second breakthrough
- Experience:40mg smoked – Ego death and unity with a friend
- Experience:50mg (approx.)/ Marijuana – Geometric Angels
- Experience:50mg – Demon faces and déjà vu
- Experience:50mg – Truth
- Experience:75mg DMT – Experiencing Death
- Experience:80mg – progressing deeper into states of unity and interconnectedness
- Experience:An Excessive Amount – N,N DMT / Marijuana – Stuck Inside an Egg
- Experience:DMT: 1,1mg 1/5 changa x3 – The continuation
- Experience:DMT: 200mg 1/5 changa – Bad yet glorious trip
- Experience:Unknown dosage (smoked) – It felt like I was on rails the whole time
Additional experience reports can be found here:
When smoked or vaporized at moderate to heavy dosages, the DMT experience manifests itself in a consistent progressive sequence which is described below.
1. “Breaking Through”
The first step of a DMT trip is the come up that leads onto an experience commonly referred to as “breaking through.” This seems to have at least a few different ways of presenting itself to the user.
The first thing that a person notices is an extremely distinct set of visual enhancements such an increase in visual acuity and colour intensity. This is followed by a sudden onset of high level 3 geometry which increases in its intensity until it envelopes and covers the external environment. These effects are often accompanied by auditory hallucinations such as soft crackling sounds or high pitched extended tones. There is also the possibility of accompanying physical sensations as one “breaks through.” These can include feelings of suddenly being pushed through and onto the other side of a membrane or feelings of shooting through space at high speeds.
2. “The Waiting Room”
Almost immediately after a person has inhaled enough DMT to have “broken through”, they often find themselves spending a brief amount of time in what is sometimes described as a psychedelic “waiting room” or “loading screen.” The appearance of this space can assume a seemingly infinite variety of forms but generally appears in the shape of an enveloping tunnel comprised of rapidly shifting, interlocking geometry. This lasts approximately 10 – 20 seconds and feels qualitatively different from other stages of the experience.
3. “The Other Side”
Once the waiting period is over, the user will feel that they have “broken through” onto the other side. It is here where users experience intense level 7 geometry and level 3 – 4 internal hallucinations. It is worth noting that although experiences vary between individuals, DMT trips often follow common archetypes, scenarios, content, and plots. These scenarios generally consist of visiting what appears to be an alternate reality that is often described to contain autonomous entities, settings, sceneries, and landscapes as well as themes of a cosmic, transcendental, or transpersonal nature.
4. “Drifting Down”
The final stage is experienced as the sensation of being pulled further and further away from the scenario until it is no longer visible and one finds themselves back in reality. This is typically accompanied by level 3 – 4 geometry as well as a sense of general exhilaration and awe. The moderate to mild geometry stays for a further 10 – 15 minutes before disappearing completely, sometimes leaving a noticeable “body high” that lingers for up to an hour.
Natural plant sources
Mimosa hostilis root bark
Mimosa hostilis (also known as Mimosa tenuiflora, Jurema and Tepezcohuite) is a perennial tree or shrub native to the northeastern region of Brazil and is found as far north as southern Mexico. Around 1% of the dried weight is DMT. It is legal to purchase online in many parts of the world and a commonly used source for performing DMT extractions or brewing into ayahuasca.
Acacia confusa root bark
Acacia confusa (also known as Acacia Petit Feuille, Small Philippine Acacia, Formosa Acacia (Taiwan Acacia) and Formosan Koa) is a perennial tree native to South-East Asia. It is legal to purchase online and easily accessible in many parts of the world. The plant matter itself contains the following chemicals:
- N-Methyltryptamine: 1.43% (not psychoactive without MAOI)
- DMT/N,N-Dimethyltryptamine: 1.15%
Preparation methods for this compound within our tutorial index include:
- DMT extraction using sodium hydroxide and naphtha
- Acid-base DMT extraction, based on Marsofold’s tek
- D-Limonene and vinegar DMT extraction
- Norman Tek
- DMT ingestion methods
Toxicity and harm potential
DMT is considered to be non-addictive, is not associated with any form of neurotoxicity, and has an extremely low toxicity relative to dose. As with other psychedelic substances, there are relatively few physical side effects associated with acute DMT exposure. Various studies have shown that in reasonable doses in a careful context, it has little to no negative cognitive, psychiatric or physical consequences.
However, as with psychedelics generally, DMT is thought to be able to act as a potential trigger for those with underlying psychiatric conditions. Those with a personal or family history of mental illness are advised not to use this substance unless under medical supervision.
Despite the lack of physical risks, it is highly advised to approach this substance with extreme caution and harm reduction practices due to the lasting mental imprint it can leave on the user.
Tolerance and addiction potential
DMT is not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is generally considered to have a built-in, self-regulating aspect. This can either occur subconsciously or even during the experience itself in which an autonomous entity will seemingly warn the user to discontinue their usage.
Tolerance to the effects of DMT does not occur. DMT presents cross-tolerance with no other psychedelics, meaning that after the consumption of DMT psychedelics will not have a reduced effect.
Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- Lithium – Lithium is often used as treatment for bipolar disorder and other conditions. It has been strongly linked to an elevated risk of seizures and psychosis, likely due to its glutaminergic and GABAergic effects.
- Tramadol – Tramadol lowers the seizure threshold and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.
- Stimulants – Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.
- International: DMT is classified as a Schedule I drug under the United Nations 1971 Convention on Psychotropic Substances, meaning that international trade in DMT is supposed to be closely monitored and its use is supposed to be restricted to scientific research and medical use. Natural materials containing DMT, including ayahuasca, are not regulated under the 1971 Psychotropic Convention.
- Australia: Between 2011 and 2012, the Australian government was considering changes to the Australian Criminal Code that would classify any plants containing any amount of DMT as “controlled plants”.
- Brazil – Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344. Rules are relaxed regarding religious use.
- Canada: DMT is a Schedule III drug.
- Estonia: DMT is a Schedule I drug.
- Germany: The production, distribution, or possession of DMT is illegal.
- Latvia: DMT is a Schedule I drug.
- New Zealand: DMT is classified in New Zealand as a Class A drug under the Misuse of Drugs Act 1975.
- Norway: DMT is a Schedule I drug.
- Russia: The production, distribution, or possession of DMT is illegal.
- United Kingdom: DMT is a Class A drug.
- United States: DMT is a Schedule I drug. Rules are relaxed regarding religious use, however. In the US, dried root bark of Mimosa hostilis had been considered a “grey area” item for a long time. However, recent efforts by the DEA appear to be focusing on eliminating internet sales of the bark, citing 21 USC § 841, which states that “(IV) any compound, mixture, or preparation which contains any quantity of any of the substances referred to in subclauses (I) through (III)” is also considered an illegal substance. Many USA based vendors have since been stocking Acacia Confusa bark as a result due to its very similar alkaloid content.